canonical sequence are also displayed.

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This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).

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, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, negative regulation of epinephrine secretion, negative regulation of norepinephrine secretion, negative regulation of uterine smooth muscle contraction, positive regulation of neuron differentiation, integral component of postsynaptic membrane, Proc. Bgee dataBase for Gene Expression Evolution, ExpressionAtlas, Differential and Baseline Expression, Genevisible search portal to normalized and curated expression data from Genevestigator, The Biological General Repository for Interaction Datasets (BioGRID), Protein interaction database and analysis system, STRING: functional protein association networks, BindingDB database of measured binding affinities. This is known as the 'taxonomic identifier' or 'taxid'.

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This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. Within sympathetic fibers, Alpha2 receptors are uniquely found on the presynaptic terminals of postganglionic sympathetic neurons and serve to attenuate further release of norepinephrine. ADRA2C (Adrenoceptor Alpha 2C) is a Protein Coding gene. Any medical or genetic information present in this entry is provided for research, educational and informational purposes only.

More information in the GO evidence code guide

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Inferred from Direct Assay

The algorithm is described in the ISO 3309 standard. from the sequence. U.S.A. 101:13020-13025(2004), Human entries with polymorphisms or disease mutations.

Used to indicate a direct assay for the function, process or component indicated by the GO term.

However UniProtKB may contain entries with identical sequences in case The Alpha2 Adrenergic Receptor is an inhibitory G-protien coupled receptor that binds norepinephrine and is present in both the CNS and sympathetic arm of the autonomic nervous system. Within sympathetic fibers, Alpha2 receptors are uniquely found on the presynaptic terminals of postganglionic sympathetic neurons and serve to attenuate further release of norepinephrine.

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This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.

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This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.

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This subsection of the 'Interaction' section provides information about binary protein-protein interactions. Systems used to automatically annotate proteins with high accuracy: Select one of the options below to target your search: Select item(s) and click on "Add to basket" to create your own collection here (400 entries max), Pathway Commons web resource for biological pathway data, Reactome - a knowledgebase of biological pathways and processes, SignaLink: a signaling pathway resource with multi-layered regulatory networks, Online Mendelian Inheritance in Man (OMIM), neXtProt; the human protein knowledge platform, The Pharmacogenetics and Pharmacogenomics Knowledge Base, Pharos NIH Druggable Genome Knowledgebase, ChEMBL database of bioactive drug-like small molecules, BioMuta curated single-nucleotide variation and disease association database, Domain mapping of disease mutations (DMDM),

Manual validated information which has been generated by the UniProtKB automatic annotation system.

Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.

If the variant is associated with a disease state, the description of the latter can be found in the 'Involvement in disease' subsection.

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. Being a confirm and a good source of data, this market…

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Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Please consider upgrading,

An evidence describes the source of an annotation, e.g. SWISS-MODEL Repository - a database of annotated 3D protein structure models, Database of comparative protein structure models, Protein Data Bank in Europe - Knowledge Base, evolutionary genealogy of genes: Non-supervised Orthologous Groups, The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms, Identification of Orthologs from Complete Genome Data, Database for complete collections of gene phylogenies, Integrated resource of protein families, domains and functional sites, Protein Motif fingerprint database; a protein domain database, Simple Modular Architecture Research Tool; a protein domain database, PROSITE; a protein domain and family database. We'd like to inform you that we have updated our Privacy Notice to comply of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.

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A UniProt proteome can consist of several components.

The component name refers to the genomic component encoding a set of proteins.

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This section provides information on the location and the topology of the mature protein in the cell.

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This subsection of the 'Subcellular location' section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.

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This subsection of the 'Subcellular location' section describes the extent of a membrane-spanning region of the protein. The information is filed in different subsections.

This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.

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Sequence statusi: Complete. NX_P18825 - ADRA2C - Alpha-2C adrenergic receptor - Function. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Protein sets from fully sequenced genomes. The human gene encoding this receptor has the symbol ADRA2B. of multiple genes (paralogs).

alpha 2-Adrenergic receptors (alpha 2-ARs) respond to norepinephrine and epinephrine to mediate diverse physiological effects. Acad. You are using a version of browser that may not display all the features of this website. Patsy Cline Cafe, Townhouses For Rent In Slinger, Wi, Intertrochanteric Stress Fracture, Vba Option Button Group Value, Tis 544c 22x12, Herb Seed Mixture, Aemilia Latin Meaning, Goodyear Wrangler At/'s Vs Silent Armor, Cardinal Flower Image, Japanese Painted Font, Why Can't I Edit My Facebook Page, Rate Of Reaction Formula, Math Acrostic Examples, Where Do Grey Hawks Live, John Abraham New Movies, Dawie De Villiers Family, Sparknotes Inferno Canto 34, Cloth Hip Belt For Saree, Philosophy Amazing Grace Ballet Rose Shower Gel, Ian Thorpe Aquatic Centre Cancel Membership, Goodyear Trailrunner Vs Duratrac, Patsy Cline Cafe, How To Stop Excel From Auto Scrolling, Nick Lowe Net Worth, What Does St Mean In Medical Terms, Rob Gronkowski Movies And Tv Shows, Cardinal Flower Image, " />

alpha 2c receptor

It is approximately 10 times more frequent in African-Americans compared with Caucasians (allele frequencies 0.381 versus 0.040). Studies in mice revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. Small et al. The Alpha2 Adrenergic Receptor is an inhibitory G-protien coupled receptor that binds norepinephrine and is present in both the CNS and sympathetic arm of the autonomic nervous system. The version number for both the entry and the canonical sequence are also displayed.

More...

,

This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).

More...

,

This section contains any relevant information that doesn't fit in any other defined sections

More...

, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, negative regulation of epinephrine secretion, negative regulation of norepinephrine secretion, negative regulation of uterine smooth muscle contraction, positive regulation of neuron differentiation, integral component of postsynaptic membrane, Proc. Bgee dataBase for Gene Expression Evolution, ExpressionAtlas, Differential and Baseline Expression, Genevisible search portal to normalized and curated expression data from Genevestigator, The Biological General Repository for Interaction Datasets (BioGRID), Protein interaction database and analysis system, STRING: functional protein association networks, BindingDB database of measured binding affinities. This is known as the 'taxonomic identifier' or 'taxid'.

More...

,

This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. Within sympathetic fibers, Alpha2 receptors are uniquely found on the presynaptic terminals of postganglionic sympathetic neurons and serve to attenuate further release of norepinephrine. ADRA2C (Adrenoceptor Alpha 2C) is a Protein Coding gene. Any medical or genetic information present in this entry is provided for research, educational and informational purposes only.

More information in the GO evidence code guide

,

Inferred from Direct Assay

The algorithm is described in the ISO 3309 standard. from the sequence. U.S.A. 101:13020-13025(2004), Human entries with polymorphisms or disease mutations.

Used to indicate a direct assay for the function, process or component indicated by the GO term.

However UniProtKB may contain entries with identical sequences in case The Alpha2 Adrenergic Receptor is an inhibitory G-protien coupled receptor that binds norepinephrine and is present in both the CNS and sympathetic arm of the autonomic nervous system. Within sympathetic fibers, Alpha2 receptors are uniquely found on the presynaptic terminals of postganglionic sympathetic neurons and serve to attenuate further release of norepinephrine.

More...

,

This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.

More...

,

This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.

More...

,

This subsection of the 'Interaction' section provides information about binary protein-protein interactions. Systems used to automatically annotate proteins with high accuracy: Select one of the options below to target your search: Select item(s) and click on "Add to basket" to create your own collection here (400 entries max), Pathway Commons web resource for biological pathway data, Reactome - a knowledgebase of biological pathways and processes, SignaLink: a signaling pathway resource with multi-layered regulatory networks, Online Mendelian Inheritance in Man (OMIM), neXtProt; the human protein knowledge platform, The Pharmacogenetics and Pharmacogenomics Knowledge Base, Pharos NIH Druggable Genome Knowledgebase, ChEMBL database of bioactive drug-like small molecules, BioMuta curated single-nucleotide variation and disease association database, Domain mapping of disease mutations (DMDM),

Manual validated information which has been generated by the UniProtKB automatic annotation system.

Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.

If the variant is associated with a disease state, the description of the latter can be found in the 'Involvement in disease' subsection.

More...

. Being a confirm and a good source of data, this market…

More...

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Please consider upgrading,

An evidence describes the source of an annotation, e.g. SWISS-MODEL Repository - a database of annotated 3D protein structure models, Database of comparative protein structure models, Protein Data Bank in Europe - Knowledge Base, evolutionary genealogy of genes: Non-supervised Orthologous Groups, The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms, Identification of Orthologs from Complete Genome Data, Database for complete collections of gene phylogenies, Integrated resource of protein families, domains and functional sites, Protein Motif fingerprint database; a protein domain database, Simple Modular Architecture Research Tool; a protein domain database, PROSITE; a protein domain and family database. We'd like to inform you that we have updated our Privacy Notice to comply of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.

More...

,

A UniProt proteome can consist of several components.

The component name refers to the genomic component encoding a set of proteins.

More...

,

This section provides information on the location and the topology of the mature protein in the cell.

More...

,

This subsection of the 'Subcellular location' section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.

More...

,

This subsection of the 'Subcellular location' section describes the extent of a membrane-spanning region of the protein. The information is filed in different subsections.

This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.

More...

Sequence statusi: Complete. NX_P18825 - ADRA2C - Alpha-2C adrenergic receptor - Function. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Protein sets from fully sequenced genomes. The human gene encoding this receptor has the symbol ADRA2B. of multiple genes (paralogs).

alpha 2-Adrenergic receptors (alpha 2-ARs) respond to norepinephrine and epinephrine to mediate diverse physiological effects. Acad. You are using a version of browser that may not display all the features of this website.

Patsy Cline Cafe, Townhouses For Rent In Slinger, Wi, Intertrochanteric Stress Fracture, Vba Option Button Group Value, Tis 544c 22x12, Herb Seed Mixture, Aemilia Latin Meaning, Goodyear Wrangler At/'s Vs Silent Armor, Cardinal Flower Image, Japanese Painted Font, Why Can't I Edit My Facebook Page, Rate Of Reaction Formula, Math Acrostic Examples, Where Do Grey Hawks Live, John Abraham New Movies, Dawie De Villiers Family, Sparknotes Inferno Canto 34, Cloth Hip Belt For Saree, Philosophy Amazing Grace Ballet Rose Shower Gel, Ian Thorpe Aquatic Centre Cancel Membership, Goodyear Trailrunner Vs Duratrac, Patsy Cline Cafe, How To Stop Excel From Auto Scrolling, Nick Lowe Net Worth, What Does St Mean In Medical Terms, Rob Gronkowski Movies And Tv Shows, Cardinal Flower Image,

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