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I. Consanguinity and associated perinatal outcomes, including stillbirth. After full adjustment for factors known to be associated with poor mental health, multilevel logistic regression models found that children of first-cousin consanguineous parents were more than 3 times as likely to be in receipt of antidepressant or anxiolytic medications (odds ratio, 3.01; 95% CI, 1.24-7.31) and more than twice as likely to be in receipt of antipsychotic medication (odds ratio, 2.13; 95% CI, 1.29-3.51) compared with children of nonrelated parents. The results illustrate a clear increasing, stepwise association between level of consanguinity and mental ill health, suggesting a quasi–dose-response association, supporting a causal association between consanguineous parents and mental health of progeny. MA. All Rights Reserved. A CHI-to-HCN lookup was created matching individuals on name, address, and date of birth and allowing a present HCN to be assigned to the historical CHS data set. To investigate if children of consanguineous parents are at increased risk of common mood disorders or psychoses. et al; CONVERGE Consortium, CARDIOGRAM Consortium, GERAD1 Consortium. Van Lieshout Paternal age and mental health of offspring. MM. The mother’s address at the time of the child’s birth was used to assign area-level deprivation.41 Areas are ranked from most affluent to most deprived based on the number of households in receipt of income-related state benefits and tax credits. The prevalence, distribution, and mental health correlates of perceived discrimination in the United States. Likelihood ratio tests for interactions found no interaction between rurality and consanguinity (χ2 = 6.37, P = .38) or between deprivation and consanguinity (χ2 = 7.99, P = .63). Bener Births were identified as singleton (n = 357 351) or multiple (n = 6609) to allow for sensitivity analyses limited to singleton births only. Consanguineous marriages have been practiced since the early existence of modern humans. D. Psychotropic medications and the transition into care: a national data linkage study. Mumtaz In this population-wide cohort study of 363 960 participants, being a child of consanguineous parents was associated with having an increased likelihood of psychotropic medication use in adulthood. In the Manusmriti, blood relation marriage (on the mother's side) is prohibited for 7 generations. BMJ Publishing Group Ltd and Royal Pharmaceutical Society. M, Ross People believe that these marriages lead to increased couple stability and compatibility, stronger family ties, less divorce and domestic violence rates, transmission of property within the family, preservation of culture and social status. JF, Fischer Fumeaux Contribution of consanguinuity to polygenic and multifactorial diseases. The PDHS indicated that more than half of ever married women aged 15-49 were married to their first cousins. Main Outcomes and Measures Until now, consanguinity is widely practiced in several global communities with variable rates. Risk of transmitting genetic disease in consanguinity is much more than in normal population. N, Tantam The BNF is the standard reference digest for medications in the United Kingdom.42 Ever or never use was used for the main analysis, and sensitivity analyses were carried out using a cutoff of at least 3 months’ prescriptions, yielding similar results (eTable 1 in the Supplement). Comparison between genetic diseases with different modes of inheritance showed that recessive and multifactorial disorders had the highest values of consanguinity (78.8%, 69.8%, respectively), while chromosomal disorders had the lowest one (29.1%). TJ, Kayne However, the study design allowed for a robust examination of the mental health risk associated with consanguineous parents: the data were population wide, capturing an entire cohort born over 15 years, and contained detailed neonatal information on the individual and detailed sociodemographic information on the parents. S, Cnattingius A child of consanguineous parents is at increased risk of common mood disorders and psychoses. M, Individuals were classified as being in receipt of antipsychotic medication if they received at least 1 prescription for antipsychotics (British National Formulary [BNF] category 4.3.6) and were classified as being in receipt of medications for common mood disorders if they received at least 1 prescription for antidepressant medication (BNF category 4.3.4) or anxiolytic medication (BNF category 4.3.1) over the 5-year study period (2010-2014). Each sex contained a large age range, so only ages within 3 SDs of the mean were accepted, with all others deemed at high risk of error and placed in the “unknown” age group category. The association between being a child of second-cousin consanguineous parents and receiving medications for common mood disorders was elevated but not statistically significant at the conventional 5% level (OR, 1.31; 95% CI, 0.63-2.71). Multilevel Regression Models to Investigate the Likelihood of Antipsychotic Medication Use Given Parental Consanguinity, Adjusting for the Clustering of Individuals Within GP Practices. et al. Advancement and rapid progress of newer modalities like next-generation sequencing may be an effective means of reducing deleterious outcomes of consanguineous marriages. Unlike what many people think, their offspring are not doomed … The literature on consanguinity and mental health of progeny is scarce despite the fact that many of the factors associated with consanguineous unions are also associated with mental health. Accessibility Statement, Table 1. GL. However, a larger proportion of consanguineous offspring were younger, with 43.1% (112 of 260) of the first-cousin group aged 26 to 29 years compared with just 27.1% (93 105 of 344 183) of the nonrelated group. Northern Ireland Statistics and Research Agency. Individual-level informed consent was not required because only nonidentifiable data were made available to the research team. Lopez-Castroman S, Neale Association of early life factors and brain tumour risk in a cohort study. DB, Spencer TM. D, Montague Importance C, Murray There is increasing evidence that highly consanguineous populations are more susceptible to certain infectious diseases like tuberculosis and hepatitis B. Gupkar Alliance fields candidates for DDC polls, Denial of ads to Kashmir Reader: Editors’ Guild urges LG to intervene, Class 12 Board exams begin at 626 centres in Kashmir, Mutton shops shut in Srinagar as traders cannot afford to sell at govt rate, Biggest CASO in recent times ends after 2 days in Shopian, with no militants found, Cut branches to save trees from damage due to snow: experts, Sino-India border standoff in Ladakh expected to be resolved peacefully soon: ITBP chief. EE, Ventriglio Cowley ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Consanguinity and its relevance to clinical genetics. eFigure. Regression Analysis to Determine Likelihood of Missing HCN Given Neonatal Factors and Consanguinity of Parents, eTable 3. Conclusions and Relevance Group II: Single gene disorders. L, Sturkenboom sign up for alerts, and more, to access your subscriptions, sign up for alerts, and more, to download free article PDFs, sign up for alerts, customize your interests, and more, to make a comment, download free article PDFs, sign up for alerts and more, Archives of Neurology & Psychiatry (1919-1959), http://www.independent.co.uk/news/uk/home-news/london-borough-child-deaths-redbridge-parents-related-cousins-pakistani-families-council-report-a7741146.html, http://www.who.int/pmnch/media/news/2012/201204_borntoosoon-report.pdf, https://www.nisra.gov.uk/sites/nisra.gov.uk/files/publications/2001-census-results-key-statistics-report-tables.pdf, https://www.nisra.gov.uk/statistics/deprivation/northern-ireland-multiple-deprivation-measure-2010-nimdm2010, Schizophrenia Spectrum and Other Psychotic Disorders, FDA Approval and Regulation of Pharmaceuticals, 1983-2018, Global Burden of Skin Diseases, 1990-2017, Health Care Spending in the US and Other High-Income Countries, Life Expectancy and Mortality Rates in the United States, 1959-2017, Medical Marketing in the United States, 1997-2016, Practices to Foster Physician Presence and Connection With Patients in the Clinical Encounter, US Burden of Cardiovascular Disease, 1990-2016, US Burden of Neurological Disease, 1990-2017, Waste in the US Health Care System: Estimated Costs and Potential for Savings, Register for email alerts with links to free full-text articles.
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